Immediate-type allergies are known as Type I allergies, among which atopic dermatitis, hives, bronchial asthma, and allergic rhinitis (hay fever) are well known. In these allergies, an immunoglobulin known as IgE binds with mast cells and other white blood cells, and because antigens bind to these cells, they discharge physiologically active substances such as histamine and serotonin. This causes vasodilatation, vascular hyperlucency and other conditions, and symptoms of inflammatory response (pain, fever, red flares, and edema) appear. In this paper, experiments with mice were conducted to study the mechanisms through which hydrogen causes immediate-type (Type I) allergies to disappear. Broadly speaking, in the immune/inflammatory response, "NADPH oxidase" contributes to the response amplification effect (referred to as the "feed-forward loop" in the paper), and the section stating that "hydrogen is endowed with the effect of inhibiting this NADPH oxidase activity" plays the main role in the effect of suppressing these allergies. In other words, the effect of hydrogen against Type 1 allergies, unlike that of antihistamine, NSAIDS, or steroids, which block or suppress the main stream of immune/inflammatory responses, is claimed to "mitigate symptoms by suppressing the mechanism (feed-forward loop) that amplifies this stream; rather than shutting down the immune/inflammatory response, the portion that is in excess (the amplification effect) is suppressed". At this hospital, we frequently hear comments from patients who have been undergoing continuous hydrogen treatment, such as "This year's hay fever was mild", "I no longer have metallic allergies", "My nasal inflammation (rhinitis) was cured", and "The hives are not so bad anymore". For these reasons, the "suppression of the immune/inflammatory amplification response" approach personally makes sense. I think it is important to continue this research from a variety of perspectives.